Fighting Disease

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‘Exercise-in-a-pill’ boosts athletic endurance by 70 percent

Salk Institute scientists, building on earlier work that identified a gene pathway triggered by running, have discovered how to fully activate that pathway in sedentary mice with a chemical compound, mimicking the beneficial effects of exercise, including increased fat burning and stamina. The study, which appears in Cell Metabolism on May 2, 2017, not only

2017-05-04T06:38:34+00:00 Tags: |

Artificial Intelligence May Help Diagnose Tuberculosis in Remote Areas

Researchers are training artificial intelligence models to identify tuberculosis (TB) on chest X-rays, which may help screening and evaluation efforts in TB-prevalent areas with limited access to radiologists, according to a new study appearing online in the journal Radiology. According to the World Health Organization, TB is one of the top 10 causes of death

2017-04-30T19:17:36+00:00 Tags: |

Vaccination gaps lead to dangerous measles outbreaks in Europe

Gaps in vaccination coverage against measles have led to several outbreaks of the highly-contagious disease in Europe in the past year, with both children and young adults affected, health officials said on Monday. During the first two months of 2017, more than 1,500 measles cases were reported from 14 European countries due to "an accumulation

2017-04-24T08:13:29+00:00 Tags: , |

Ebola virus response: experiences and lessons from Sierra Leone

It’s 18 months since Sierra Leone was declared Ebola free after a two-year outbreak that left 4,000 people dead. While the outbreak might be over, its effects will persist for many years. In the small nation with a population of just 7 million many lost relatives and friends to the disease. And its economy which

2017-04-24T07:58:34+00:00 Tags: , |

Patients don’t know how to best manage their cholesterol

Most people with high cholesterol are not sure how to manage the potentially deadly condition, according to a survey from the American Heart Association. Nearly one in three American adults has high levels of LDL cholesterol, according to AHA statistics. It’s a serious health risk, because too much LDL — or “bad” — cholesterol can

2017-04-11T09:49:16+00:00 Tags: , |

Potential New Treatment to Treat and Stop Progression of Cystic Fibrosis

Researchers from the George Washington University (GW), the University of Perugia, and the University of Rome have discovered a potential new drug to treat and stop the progression of cystic fibrosis. Thymosin α1 (Tα1) is a novel therapeutic single molecule-based therapy that not only corrects genetic and tissue defects, but also significantly reduces inflammation seen

2017-04-11T09:37:07+00:00 Tags: , |

The first live-attenuated vaccine candidate completely protects against Zika infection

GALVESTON, Texas –The first live-attenuated Zika vaccine still in the development stage completely protected mice against the virus after a single vaccination dose, according to new research from The University of Texas Medical Branch at Galveston and Instituto Evandro Chagas at the Ministry of Health in Brazil. The findings are currently available in Nature Medicine.

2017-04-11T09:27:53+00:00 Tags: , |

MicroRNA Treatment Restores Nerve Insulation, Limb Function in Mice with MS

Scientists partially re-insulated ravaged nerves in mouse models of multiple sclerosis (MS) and restored limb mobility by treating the animals with a small non-coding RNA called a microRNA. In a study published online March 27 in Developmental Cell, researchers at Cincinnati Children’s Hospital Medical Center report that treatment with a microRNA called miR-219 restarted production

2017-03-28T06:45:17+00:00 Tags: , |

‘Huge advance’ in fighting world’s biggest killer disease

An innovative new drug can prevent heart attacks and strokes by cutting bad cholesterol to unprecedented levels, say doctors. The results of the large international trial on 27,000 patients means the drug could soon be used by millions. The British Heart Foundation said the findings were a significant advance in fighting the biggest killer in

Table Salt Can Eliminate This Crippling Disease By 2020

When Jim Reimer retired, he did not anticipate the important role he and the company would play in helping millions of Haitians combat a terrible disease. In 2012, Reimer became involved in the University of Notre Dame’s Haiti Program, which works to rid Haiti of lymphatic filariasis (LF) by 2020. LF is a disease spread

Enormous promise for new parasitic infection treatment

The human whipworm, which infects 500 million people and can damage physical and mental growth, is killed at egg and adult stage by a new drug class developed at the Universities of Manchester and Oxford and University College London. Current treatments for human whipworm are based on 1960s drugs initially developed for livestock and have

2017-03-03T07:55:54+00:00 Tags: , |

New antibiotic from bacteria found on Kenyan ant could help beat MRSA

Researchers at the University of East Anglia (UEA) and the John Innes Centre (JIC) discovered a new member of the Streptomyces bacteria family, isolated from the African fungus-growing plant-ant Tetraponera penzigi. They have named the new species Streptomyces formicae and the antibiotics formicamycins, after the Latin formica, meaning ant. Lab tests have shown these new

2017-02-15T15:05:42+00:00 Tags: , |

Cytotoxins contribute to virulence of deadly epidemic bacterial infections

Beginning in the mid-1980s, an epidemic of severe invasive infections caused by Streptococcus pyogenes (S. pyogenes), also known as group A streptococcus (GAS), occurred in the United States, Europe, and elsewhere. Potent cytotoxins produced by this human pathogen contribute to the infection, commonly known as 'flesh-eating disease.' A new study reports that the bacteria's full


Low socioeconomic status reduces life expectancy and should be counted as a major risk factor in health policy, study says

Low socioeconomic status is linked to significant reductions in life expectancy and should be considered a major risk factor for ill health and early death in national and global health policies, according to a study of 1.7 million people published by The Lancet. Read more at AlphaGalileo


Feed a cold, starve a fever? Not so fast, according to Salk research

Now, research from the Salk Institute shows how bacteria block the appetite loss response in their host to both make the host healthier and also promote the bacteria’s transmission to other hosts. This surprising discovery, published in the journal on January 26, 2017, reveals a link between appetite and infection and could have implications in


Stem cell ‘marking’ study offers alterative hypothesis of cancer metastasis

Stem cells are among the most energetically activated, migratory and proliferative sub-populations of tumour cells, according to observations by scholars at the Biomedical Research Centre at the University of Salford. Cancerous stem cells are often left behind after chemotherapy with the potential to create new tumours – a process called recurrence and metastasis. In research

2017-02-23T09:33:19+00:00 Tags: , |

Finding may explain why many Alzheimer’s disease patients wander

Columbia University Medical Center (CUMC) researchers have discovered that the spatial disorientation that leads to wandering in many Alzheimer’s disease patients is caused by the accumulation of tau protein in navigational nerve cells in the brain. The findings, in mice, could lead to early diagnostic tests for Alzheimer’s and highlight novel targets for treating this

2017-02-23T09:34:08+00:00 Tags: , |